Mg alloy surface immobilised with caerin peptides acquires enhanced antibacterial ability and putatively improved corrosion resistance

Magnesium (Mg) has mechanical properties similar to human bones and Mg alloy is considered ideal medical implant material. However, the high velocity of degradation inside inner environment severely hampers usage alloys. In this study, caerin peptide 1.9 (F3) a modified sequence 1.1 (F1) with anti-bacterial activity, were covalently immobilised on surface alloys by plasma chemical click reaction. The in vitro antibacterial activity corrosion resistance these peptide-immobilised investigated Dulbecco's Modified Eagle Medium (DMEM) solution. Un-immobilised sample, blank drug-sensitive tablet (BASD) commonly used antibiotics Tazocin for comparison. Results showed that samples observable improved prolonged effect compared non-immobilised free peptides. These results indicate coating peptides obviously increases alloy's ability putatively improves . mechanism underlying annealed (especially F3) remains unclear, which worth further experimental theoretical investigation. • Caerin Mg’s Peptide coated got better resistance, effect. behaviour than antibiotics. long-lasting behaviour. Different treatments different effects resistance.